Preparation and characterization of chitosan microspheres for controlled release of tramadol

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Chitosan microspheres cross-linked with genipin were prepared by a spray-drying method and were characterized in terms of morphology, loading efficiency, zeta potential and X-ray diffraction. The model drug used in this study was tramadol hydrochloride. In vitro drug release was also evaluated and microspheres showed controlled release kinetics.

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