Release behaviour of hydrogel microparticles based on hydroxyl-ethyl-starch as a drug delivery system for proteins


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Abstract

Abstract summaryHydrogel microparticles were produced by radical polymerisation of hydroxyethylmethacrylate-hydroxyethylstarch (HESHEMA) in an all aqueous two phase system. The microspheres show a monomodal size distribution and have the ability to entrap high amounts of water. The release of proteins or other test substances can be controlled by the choice of the network density of the hydrogel by varying the degree of substitution (DS), the size of the entrapped substance and the presence of degrading influences.

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