Thermoresponsive polymer for local chemoradiotherapy with doxorubicin boundviaa newly developed hydrolytically labile bond

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Abstract summaryA new polymeric drug delivery system designed for possible local chemoradiotherapy using injectable thermoresponsive polymer with radionuclide and doxorubicin, which serves as an antiproliferative agent and hydrophobic moiety controlling bioerosion in the same time, was synthesized and characterized. Doxorubicin is bound to the polymer carrier by a newly developed N-glycosylamine bond.

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