The RADPLAT treatment technique for advanced squamous-cell carcinoma of the upper aerodigestive tract

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Abstract

In an effort to improve outcomes for patients with advanced head and neck cancer, recent clinical trials have focused on combined-method nonsurgical therapy. The RADPLAT (radiation + platinum) technique, which uses supradose intra-arteriai cisplatin and concomitant radiation therapy, has shown promising results in phase II single-institutional studies. This article reviews this work with respect to the concept of, rationale for, therapeutic effect of, and outcome of RADPLAT. The data support further investigations of this approach, particularly with regard to organ preservation and function and the restoration of quality of life. Further confirmation of the benefits of RADPLAT will be seen upon completion of a National Cancer Institute-sponsored study involving 1 0 academic medical centers

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