The occurrence of sarcoma in conjunction with joint arthroplasty

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The development of a cancerous tumor at the site of a total joint replacement is a rare but virtually always fatal event. Recent research related to the biologic response to implant particulate wear debris suggests new mechanisms that would explain uncontrolled mesenchymal cell proliferation at loose prostheses. To date there have been 19 well-documented cases of sarcomas arising at the site of joint replacements. This incidence is higher than one would expect based on chance occurrence alone, but it still indicates that a very low risk exists for developing sarcoma at the site of an implant.

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