Osteolysis in total hip arthroplasty

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Periprostheitic osteolysis is a biologic response to particulate wear debris. Osteolysis may occur in aseptically loose and well-fixed prostheses and in both cemented and cementless total hip arthroplasties and it is the major factor in limiting the longevity of a total hip arthroplasty today. This article reviews the current data regarding the generation of particulate wear debris and the development of osteolysis in total hip arthroplasties. Potential ways to limit wear in clinical practice are also discussed.

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