Drug-device combination approaches for delivery to the eye


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Abstract

HIGHLIGHTSDrug-device combinations can overcome ocular barriers and elimination mechanisms.Anterior segment systems mainly enhance precorneal retention and tissue permeation.Posterior segment devices sustain drug release minimizing the injection frequency.While the eye is readily accessible from the outside of the body, it is a rather isolated organ with a number of barriers and elimination mechanisms in place to protect it from the environment, rendering efficient treatment difficult. To enhance drug delivery to the eye, a number of drug-device combinations have been investigated over recent decades, increasing drug retention and permeation while also allowing for sustained drug release over prolonged periods. This article will summarize recent combination systems investigated for the treatment of anterior and posterior segment conditions.

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