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Proton pump inhibitors and topical steroids are the main medical therapy for EoE.Strict adherence of a gluten-free diet is the only effective treatment for CeD.While novel drugs and biologic therapies are being tested for EoE and CeD, none are more efficacious than standard therapy.Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the only effective therapy for CeD, several therapeutic options, such as proton pump inhibitors, topical steroids and diet elimination therapy are available for EoE. For EoE patients, all can be efficacious in achieving remission, but the looming question is whether all patients should be on maintenance therapy. New biologic therapies are being studied under study in both diseases, but none are ready for clinical use.