This article focuses on the recent developments in CT imaging of chest infections in patients who are immunocompetent or immunosuppressed, but not infected with HIV. Although simple viral and bacterial infections predominate, more “exotic” infections are now being encountered. First, a re-emergence of mycobacterial disease has occurred. Second, a growing population of transplant recipients (ie, lung, solid organ, and bone marrow) is susceptible to a wide range of pathogens. These trends are reflected in the forthcoming discussion. In particular, several important articles on immunosuppressed (HIV-negative) patients and on imaging fungal disease have been written within the past year.