Shoulder pathology is of growing concern for the aging population, people who pursue an active lifestyle, and manual laborers. Rotator cuff disease and osteoarthritis represent the two most common disorders leading to shoulder pain, disability, and degeneration. The use of biologic adjuvants in the treatment of these conditions has shown promise. Platelet concentrates, scaffolds, and hyaluronic acid continue to be studied extensively to better understand the mechanism of action, clinical indications, and favored mode of application to be of greatest benefit to the pathologic shoulder. This review presents the most current literature update on the use of biologics to treat patients with shoulder disease.