Renal disease and rheumatic manifestations

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The musculoskeletal effects of renal failure are seen in a variety of tissue, including bone, joints, and soft tissue. These effects include avascular necrosis, osseous abnormalities, ligamentous laxity, destructive arthropathies, and soft-tissue calcifications. With the advent of therapy (dialysis, transplantation), a new generation of disorders affecting these tissues has emerged. In particular, a high prevalence of destructive cervical spondyloarthropathy, which may be due to β2-microglobulin type amyloidosis, can be a particularly serious problem in long-term hemodialysis patients.

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