New Finding in Vernal Keratoconjunctivitis: Splendore–Hoeppli Phenomenon

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To report 2 cases of Splendore–Hoeppli phenomenon, a rare histopathologic observation, as a late clinical finding in vernal keratoconjunctivitis (VKC).


We report the cases of 2 young women with subconjunctival nodules as a manifestation of Splendore—Hoeppli phenomenon with a history of severe VKC.


After eliminating other conditions causing such a reaction, both patients were treated using frequent topical corticosteroid, plus topical cyclosporine 2% in one of patient. Complete resolution was observed in both patients.


The Splendore–Hoeppli phenomenon could be a part of VKC manifestations.

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