Keratokyphosis in Rabbits: A Functional and Morphologic Study

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Keratokyphosis, a “nonfreeze keratomileusis” procedure, was applied in rabbits. The refractive changes were −6.5±0.7(SD), −9.5±2.6, and −13.0±3.2 D for convex applanation surfaces with a vertex of ±100 $mUm, ±125 $mUm, and ± 150 $mUm in the microkeratome and ±1.5±2.0 and ±2.5±2.6D for concave applanation surfaces with a vertex of - 100 $mUm and −125 $mUm. The pachymetric corneal changes were ±43±24 $mUm, ± 39±32 $mUm, and ± 71 ±24 $mUm for the convex applanation surfaces and −21 ±40 $mUm and −17 ± 24$mUm for the concave. Wound healing was uncomplicated. The scar at the interface was 0–5 $mUm wide. The mean central density of nerve endings was l,255±532/mm2. The endothelial cell size was 25.1% (p < 0.01) greater as measured by specular microscopy than by vital preparation technique; this difference was greater with higher (33.4%) than with lower (18.02%) corneal refraction (p = 0.02). In addition, there was a method-independent correlation (correlation coefficient, −0.63) between endothelial cell count and corneal thickness. This may indicate an increased demand on corneal endothelium in thickened corneas.

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