Current State of and Outlook for Organogenesis from Undifferentiated Cells

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PurposeThe aims of regenerative medicine and artificial internal organ development are, respectively, to regenerate and provide for transplant tissue or organs.MethodsWe summarize recent research on tissue differentiation and organogenesis using stem cells and report our laboratory's research using amphibian undifferentiated cells.ResultsWe have successfully induced differentiation in cells from Xenopus laevis and generated structures in vitro that function in a similar way to organs when transplanted to Xenopus and newt embryos. We are attempting to establish a system to induce sensory organs, including eyes.ConclusionOur experimental systems in amphibians are useful for organogenetic research, and it is hoped that our techniques can, in the future, be applied to mammals.

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