The HINTEGRA ankle was developed as an attempt to specifically address the needs of minimal bone resection, extended bone support, proper ligament balancing, and minimal contact stresses within and around the prosthesis. The purpose of this study was to determine the short-term results in a consecutive series of 116 patients (122 ankles). Preoperative diagnoses were posttraumatic osteoarthrosis in 91 ankles (75%), primary osteoarthrosis in 16 ankles (13%), and systemic arthritis in 15 ankles (12%). Eight ankles had to be revised. Four were revised because of loosening of at least one component; one because of dislocation of the meniscus; and three for other reasons. All revisions were successful. After an average of 18.9 months (range, 1–3 years), 84% of patients were satisfied, and the clinical result was rated as good or excellent in 82% of the cases. The American Orthopaedic Foot and Ankle Society hindfoot score improved from 40 points preoperatively to 85 points at followup. Eighty-three ankles (68%) were completely pain-free. The average range of motion clinically was 39° (range, 15°–55°) and under fluoroscopy (true ankle motion) it was 37° (range, 7°–62°). Radiographically, the tibial component was stable in all ankles, and no tilting of the component occurred since surgery. However, migration of the talar component was observed in two ankles. The concept of minimal bone resection and wide bony support was shown to be successful on the tibial and talar sides. Obtained function, pain relief, and patient satisfaction were promising and, compared with other devices, the results mostly were superior. This may support the idea that anatomic-shaped surfaces, as is the case in the HINTEGRA ankle, may be successful in total ankle replacement.