Determination of the ability of high-frequency ECG to estimate left ventricular mass in humans, determined by magnetic resonance imaging

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Previous studies have shown a significantly higher correlation between left ventricular mass index (LVMi) and high-frequency QRS components (HF-QRS) than between LVMi and QRS amplitudes in the standard frequency range in rabbits. The purpose of the present study was to compare ECG measurements from standard and high-frequency ranges with left ventricular mass (LVM) and LVMi determined by magnetic resonance imaging in humans.


Sixty-two normal subjects were studied. Signal-averaged ECGs from the 12 standard leads were analysed in the standard frequency range (0·05–150 Hz), in the middle (25–100 Hz) and high end (50–150 Hz) of the standard frequency range and in the 150–250 Hz range. Root-mean square (RMS) values from the HF-QRS and QRS amplitude measurements from the standard ECGs were compared with LVM and LVMi.


The correlations between LVMi and HF-QRS were similar to those between LVMi and standard ECG. When regarding LVM, however, the correlations found in the standard ECG were higher than those found in HF-QRS.


Contrary to previous results in animals, we found in humans no better correlation between HF-QRS and LVM/LVMi than between standard ECG and LVM/LVMi.

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