Does a Sedation Strategy Including Dexmedetomidine Decrease Mortality and the Need for Mechanical Ventilation in Sepsis?

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Abstract

Synopsis: Septic patients requiring mechanical ventilation did not have decreased mortality or fewer ventilator days if given light sedation that included dexmedetomidine.

Source: Kawazoe Y, Miyamoto K, Morimoto T, et al. Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis (DESIRE). JAMA. 2017;317(13): 1321–1328.

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