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Synopsis: Data are mixed and controversial with regard to the literature on varenicline causing increased cardiovascular complications. The authors of this study determined that there may be a 34% higher risk of cardiovascular complications associated with the use of varenicline, compared with no use.Source: Gershon AS, Campitelli MA, Hawken S, et al. Cardiovascular and neuropsychiatric events after varenicline use for smoking cessation. Am J Respir Crit Care Med. 2018;197:913–922.