Open-Lung Ventilation in ARDS is Not Necessarily Lung Protective

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Mr. Kallet reports no financial relationships relevant to this field of study.


Two large, prospective, multicenter, randomized, controlled trails (OSILLATE and OSCAR) compared high-frequency oscillatory ventilation (HFOV) to either a high-PEEP approach to open-lung ventilation or usual care (lung-protective ventilation). In the first study, HFOV using relatively high mean airway pressures was stopped early due to significantly higher hospital mortality in the HFOV group. The second study found no difference in mortality.


Ferguson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 2013;368:795-805. Young D, et al. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 2013;368:806-813.

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