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This article offers a definition of the transdisciplinary inquiry approach (Montuori, 2010) and demonstrates how this approach can benefit the nursing profession in our process of shifting our paradigm toward caring, love, and healing. The article provides an example of a transdisciplinary approach to change process in nursing. It considers the phenomenon of resistance to change in nursing academia, which has created obstacles to revising pedagogical processes, resulting in ongoing difficulties in creating change in the practice setting. A model based on transdisciplinary practices for creative change in nursing is described.