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The University of Washington School of Nursing faculty partnered with leaders of a local community with the shared intention of improving health services for needy populations and preparing nursing students to collaborate with communities in caring for such populations. The resulting clinic has operated for more than a decade and has continually grown, now serving about 1,000 patients per month. More than 300 students have completed clinical or research activities at the clinic. Challenges have included provision of culturally informed, evidence-based care; integration of mental and primary health care services; chronic disease management; leveraging community partnerships in support of needy populations; and fiscal sustainability. A new project uses teambased approaches to implement interprofessional, relationship-centered care for families of newborns.