Influence of Renal Prostaglandin Synthesis on Renin Control Mechanisms in the Dog

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Abstract

SUMMARY

We studied the influence of altered rates of intrarenal prostaglandin synthesis on known renin control mechanisms in single, filtering and nonfiltering, denervated kidneys of chloralose, anesthetized dogs. Infusion of indomethacin directly into the renal artery resulted in 50% reductions in both renin and prostaglandins effluxing from the renal vein. The increased plasma renin resulting from suprarenal aortic constriction was unaffected by indomethacin despite suppressed renal vein prostaglandin efflux. However, the renin response to furosemide was blunted by prior renal arterial indomethacin administration even though furosemide had no influence on prostaglandin efflux. Renin secretion also was suppressed by intrarenal indomethacin administration in nonfiltering kidneys. Intrarenal arachidonic acid infusion resulted in parallel increases in renin and prostaglandin in both papaverine-treated and untreated, nonfiltering, denervated kidneys. Imposition of intrarenal indomethacin during arachidonic acid infusion in nonfiltering kidneys suppressed prostaglandin efflux from both papaverinize-treated and untreated kidneys; however, renin secretion was suppressed by indomethacin in only the control kidney. Since renin was stimulated by arachidonic acid in nonfiltering, denervated, papaverine-treated kidneys, it is concluded that the in vivo intrarenal cyclooxygenase-dependent conversion of arachidonic acid to prostaglandins exerts its influence on renin secretion by a direct influence on juxtaglomerular cells and is independent of other presently recognized renin control mechanisms. Ore Res 45:13-25, 1979

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