Pulmonary Vasodilator Activity of Prostacyclin (PGI2) in the Cat

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We studied the pulmonary vascular effects of prostacyclin, PGI2, in the cat with intact chest under conditions of controlled blood flow. Intralobar injections of PGI2, 0.03-1 fig, decreased arterial pressure in the perfused lobe in a dose-dependent manner. Inasmuch as lobar blood flow was held constant and left atrial pressure was unchanged, the fall in lobar arterial pressure reflects a decrease in lobar vascular resistance. Prostaglandin Et (PGE1) and nitroglycerin also decreased lobar arterial pressure; however, PGI2had greater vasodilator activity than did these substances. Vasodilator responses to PGI2, PGE1, and nitroglycerin in absolute terms were dependent on the baseline level of tone in the pulmonary vascular bed. Prostacyclin reversed the hypertensive and platelet aggregating effects of ADP in the lobar vascular bed. These data indicate that PGIi has significant vasodilator activity in the feline pulmonary lobar vascular bed. Circ Res 45: 404-409, 1979

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