Suppression of Renin Secretion in the Rat Kidney by a Nonvascular a-Adrenergic Mechanism

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Abstract

SUMMARY

We studied the effect of a-adrenergic stimulation, using phenylephrine, on basal and isoproterenol-provoked renin secretion in the isolated perfused rat kidney. Infusion of phenylephrine increased renal perfusion pressure and prevented the response in renin secretion to isoproterenoL No suppression of basal secretion was observed. Renal vasoconstriction was abolished, and the response in renin secretion to isoproterenol was restored by a-adrenoceptor blockade with phenoxybenzamine. In contrast, when renal vasoconstriction was prevented by dihydralazine, suppression of renin release by phenylephrine still occurred. These observations support an inhibitory effect of a nonvascular a-adrenergic mechanism on renin release. We suggest that the a receptor mediating this effect is related directly to the juxtaglomerular cell. Ore Res 45: 435-439, 1979

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