Abstract 109: Interleukin 17 A, Coronary Artery Disease And Gender of The Patients

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Abstract

Introduction: The effects of interleukins during development of coronary artery disease (CAD) have been studied by researchers and it may help to understand better this disease. The aim of this study was to evaluate if there are differences of concentrations of the IL 17 A between men and women with stable CAD.

Hypothesis: There are no differences of concentrations of the IL 17 A according to gender of the patients.

Methods: This is a cross-sectional, prospective, analytical study, conducted from August to December 2012. We included 40 patients (24 men (MP) and 16 women (WP) with stable CAD, CCS III or IV, ischemic myocardial scintigraphy, who had not been subjected to any kind of myocardial revascularization and with coronary stenosis ≥ 50% according to current coronary angiography. There were 20 healthy volunteers (12 men (MC) and 8 women (WC), to take up comparison of concentrations of interleukins (IL). Interleukins were evaluated in serum of patients and after 48 hours of cells in culture with and without stimulus. IL concentrations were expressed in pg / ml. Statistical analysis was performed using the Mann-Whitney or Student t test. P ≤ 0,05 was considered statistically significant.

Results: The comparison between the groups showed:

IL 17 A: Serum: MP = 3.91 (3.91 - 3.91) vs MC = 3.91 (3.91 - 9.28), p = 0.31; culture 48 hours without stimulus: MP = 3.91 (3.91 - 3.91) vs MC = 3.91 (3.91 - 3.91), p = 0.45; culture 48 hours with stimulus: MP = 451.67 (99.02 - 892.58) vs MC = 135 (3.91 -- 285), p = 0.04.

IL 17 A: Serum: WP = 3.91 (3.91 - 3.91) vs WC = 3.91 (3.91 -- 6.25), p = 0.90; culture 48 hours without stimulus: WP = 3.91 (3.91 - 3.91) vs WC = 3.91 (3.91 -- 3.91), p = 0.20; culture 48 hours with stimulus: WP = 131.21 (3.91 - 231.97) vs WC = 173.78 (3.91 - 642), p = 0.24.

IL 17 A: Serum: MP = 3.91 (3.91 - 3.91) vs WP = 3.91 (3.91 - 3.91), p = 0.17; culture 48 hours without stimulus: MP = 3.91 (3.91 - 3.91) vs WP = 3.91 (3.91 - 3.91), p = 0.47; culture 48 hours with stimulus: MP = 451.67 (99.02 -- 892.58) vs WP = 131.21 (3.91 - 231.97), p = 0.02.

Conclusions: There were no differences of concentrations of the IL 17 A between WP and WC. However, MP had higher concentrations of the IL 17 A than MC and WP. Therefore, it is possible that the IL 17 A take part in a pathway which determines different patterns of CAD according to gender.

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