Issn Print: 0193-1091
Publication Date: 1997/10/01
Jessner-Kanof's Lymphocytic Infiltration of the Skin: A Classification Based on an Immunohistochemical Study: 93
Excerpt
This study is based on an investigation of 187 cases of lymphocytic infiltration of the skin (LIS), to the best of our knowledge the largest study so far. All histopathological slides were reviewed with H+E sections as well as stained with the monoclonal antibodies CD20, CD21, CD43, Mac 387, S100 and PCNA. LIS was characterized by the following: sharply demarcated infiltrates of T-lymphocytes, in 70% to 90% of the cellular infiltrates, not involving the epidermis. Monocytes are mostly located in the peripheral zone. CD21-positive cells were missing in the infiltrates. S100- as well as PCNA-positive cells were seldom found. B-cells were seen between 1% and 50% of the cellular infiltrates. We therefore propose that LIS is a heterogenous dermatosis which should be divided into three immunophenotypically different entities, i.e. type 1: infiltrates with only T-cells (type 1a: T-cells of a mixture of CD4 and CD8, type 1b: T-cells with predominantly CD4), type 2: infiltrates of T-cells mixed with B-cells (perivascular lymphocytoma), type 3: infiltrates of T-cells with B-cells without a special correlation to vascular structures. It is our conclusion that only type 1 with solely T-cell infiltrates corresponds to LIS as described by Jessner and Kanof.
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