Histiocytosis X (Langerhans' cell granulomatosis) of the thymus: A clinicopathologic study of four childhood cases

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Abstract

ABSTRACT

Four cases of histiocytosis X (Langerhans' cell granulomatosis) involving the thymus are presented. All the patients were children, their age at diagnosis ranging from 2 months to 8 years. In two cases, the disease seemed restricted to the thymus; in the other two, there was extrathymic involvement. The treatment was generally in the form of surgical excision. All the patients are alive and well on follow-up.

The light-microscopic appearance was that classically described for histiocytosis X in all cases. Staining for S-100 protein was strongly positive in the two cases in which it was carried out.

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