Hepatosplenic αβ T-Cell Lymphoma: An Unusual Case With Clinical, Histologic, and Cytogenetic Features of γδ Hepatosplenic T-Cell Lymphoma

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Hepatosplenic γδ T-cell lymphoma is a recently identified entity in which lymphoma cells bearing the γδ T-cell receptor (TCR) infiltrate the sinusoids of the liver and the sinuses of the splenic red pulp and bone marrow, without lymph node involvement. It is also characterized by a recurrent cytogenetic finding, isochromosome 7q (i7q10). The authors report a case of hepatosplenic lymphoma of αβ T-cell phenotype that shares the same clinical, histologic, and cytogenetic characteristics of the previously described hepatosplenic γδ T-cell lymphoma. Fluorescent in situ hybridization performed with chromosome 7 probes showed the typical pattern of isochromosome 7q. Genomic analysis of the TCR γ locus failed to detect a clonal rearrangement. This unique case of hepatosplenic lymphoma of αβ T-cell phenotype supports the possibility that lymphoid populations of different αβ or γδ phenotype that share similar homing and presumably functional properties could give rise to lymphomas displaying similar clinical and pathologic findings.

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