Partition Coefficients for Sevoflurane in Human Blood, Saline, and Olive Oil

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Abstract

The purpose of this study was to determine partition coefficients for a new rapid-acting inhaled anesthetic, sevoflurane. Blood samples were taken from 19 ASA physical status I-III patients ranging in age from 21 to 77 yr who were scheduled for elective surgery. At 37°C, we found a blood/gas partition coefficient of 0.686 ± 0.047 (mean ± SD), a saline/gas partition coefficient of 0.370 ± 0.016; and an oil/gas partition coefficient of 47.2 ± 2.7. These values are consistent with the clinical observation that sevoflurane is a potent inhaled anesthetic that produces a rapid induction of and recovery from anesthesia.

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