PMID: 8638810

Issn Print: 0003-2999

Publication Date: 1996/06/01


Print

Meningitis After Injection of Intrathecal Baclofen

Francisco A. Naveira; Kevin L. Speight; Richard L. Rauck; Randall L. Carpenter

    loading  Checking for direct PDF access through Ovid

Excerpt

Baclofen has been used for the control of muscle spasms since 1978 [1]. Yaksh and colleagues [1,2] examined its efficacy after intrathecal use in the early 1980s. First used intrathecally by Penn and Kroin in 1983 [3,4], baclofen was found to possess analgesic properties and to cause profound muscle relaxation in the primate model. Intrathecal baclofen has been developed as a muscle relaxant as well as an antispasmodic drug for the management of refractory spasticity from spinal cord trauma [5-7].
With the initiation of any new drug delivery system, one can expect side effects not previously reported. With the delivery of drugs into the subarachnoid space, it is important to know which drugs have the ability to produce idiosyncratic reactions including aseptic meningitis. We present the following as the first reported case of aseptic meningitis, versus chemical meningitis, after an intrathecal baclofen trial.

Related Topics

    loading  Loading Related Articles