The Effect of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Trial

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BACKGROUND:In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort.METHODS:One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured.RESULTS:Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups.CONCLUSIONS:Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.

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