DOI: 10.1213/01.ane.0000492820.59016.06
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Issn Print: 0003-2999
Publication Date: 2016/09/01
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Excerpt
Materials & Methods: randomized, double-blind prospective study including 40 patients ASA I or II, admitted for surgery for fracture of the femoral neck under spinal anesthesia. They are divided into 2 groups: GC (injection of 10 mg of bupivacaine hyperbare0,5% + 15 µg clonidine) and GD (10 mg hyperbaric bupivacaine + 3μg dexmedetomidine) neither the patient nor the pharmacologist know the nature of the adjuvant.another anesthesiologist who assured only transport of samples, evaluates the time and duration of sensory block (prick-touch test at T12) and motor (modified Bromage score> 2)
Venous blood samples of 3 ml were obtained before bupivacaine injection and immediately after spinal injection and at 5, 10, 30, 45, 60, 120,240 min and 24 hours after the final injection. The plasma separated by centrifugation of blood samples and stored at −20°C until use. Bupivacaine quantification in samples was carried out using high performance liquid chromatographic method with ultraviolet absorbance detection (λ =207 nm). Statistic study with SPSS22.
Results:
Conclusion: Dexmedetomidine decreases the systemic absorption of bupivacaine compared to clonidine during spinal anesthesia, which could explain the extension of sensory block.
References:
ELJEBARI H et al.Population pharmacokinetics of bupivacaine in combined lumbar and sciatic nerve block 2014;46:201-6.
