Renal Effects and Metabolism of Sevoflurane in Fischer 344 Rats: An In-vivo and In-vitro Comparison with Methoxyflurane

Abstract

Sevoflurane, 1.4 per cent (MAC), was administered to groups of Fischer 344 rats for 10 hour, 4 hours, or 1 hour; additional rats received 0.5 per cent methoxyflurane for 3 hour or 1 hour. Urinary inorganic fluoride excretion of sevoflurane in cico was a third to a fourth that of methoxyflurane. However, using hepatic microsomes, sevoflurane and methoxyflurane were defluorinated in citro at essentially the same rate. The discrepancy between defluorination of sevoflurane and methoxy-flurane in cico and in citro was probably due to differences in tissue solubility between the drugs. There were no renal functional or morphologic defects following sevoflurane administration. An unexplained adverse effect was significant weight loss, which occurred following all exposures to sevoflurane.