Effects of Halothane on Glutamate Receptor-mediated Excitatory Postsynaptic Currents: A Patch-Clamp Study in Adult Mouse Hippocampal Slices

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BackgroundThe effects of halothane on excitatory synaptic transmission in the central nervous system of mammals have been studied in vivo and in vitro in several investigations with partially contradicting results. Direct measurements of the effects of halothane on isolated glutamate receptor-mediated (glutamatergic) excitatory postsynaptic currents (EPSCs), however, have not been reported to date.

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