Gender and Post–Dural Puncture Headache
Gender is believed to be an independent risk factor for the development of post–dural puncture headache, but there are some of the inconsistencies in the available data. This systematic review examined a total of 18 trials (2,163 males, 1,917 females). The odds of developing a post–dural puncture headache were significantly lower for male than nonpregnant female subjects (odds ratio = 0.55; 95% confidence interval, 0.44–0.67). Although the authors found that nonpregnant female subjects seem to have a higher incidence of post–dural puncture headache than males, the etiology behind these findings is not clear from the current meta-analysis.