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There is currently little agreement among surgeons regarding the dressing of choice for split-thickness skin graft donor sites, though many are available. In this article, I review the five major groups of dressings, open, semiopen, occlusive, semiocclusive, and biological. The different dressings in each group are described in terms of physiological basis for use, advantages, disadvantages, and practical application. Conclusions are reached regarding which donor site dressings might come closest to optimal for common clinical situations.