Amantadine and rimantadine resistance in influenza A viruses

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Drug-resistant H3N2 subtype influenza A viruses have emerged during rimantadine treatment of uncomplicated influenza in children and adults. Illness due to the apparent transmission of resistant viruses and the associated failures of drug prophylaxis have occurred in household contacts receiving rimantadine and nursing-home residents receiving amantadine. However, treatment is accompanied by clinical benefits, despite the recovery of resistant viruses from some treated patients. The available data indicate that the risks of resistant viruses emerging do not outweigh the documented benefits of drug prophylaxis and therapy in most circumstances

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