Newer beta-lactam antibiotics

Abstract

After many years, new broad-spectrum β-lactam drugs have become available for clinical use. Meropenem, unlike imipenem, can be administered as a single agent, is useful in the treatment of meningitis and is better tolerated. Cefepime, a fourth-generation cephalosporin, is effective against ceftazidime-resistant Gram-negative bacilli such as Pseudomonas and Enterobacter. Both drugs have advantages over existing compounds, and are expected to be used in a restricted fashion in the hospital environment.