Computational genetic discoveries that could improve perioperative medicine

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Purpose of review

The review examines the rationale and translational utility of computational genetic studies using murine models of biomedical traits.

Recent findings

Computational genetic mapping studies have identified the genetic basis for biomedical trait differences in 16 different murine models, including several that are of importance to perioperative medicine.


The results have generated new treatments for alleviating incisional pain and narcotic drug withdrawal symptoms, which are now in clinical trials. A recent study identified allelic differences affecting chronic pain responses in mice and humans, which may enable a new ‘personalized’ approach to treating chronic pain.

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