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University students represent the national capital and investment for the future, with an implicit mission both for their families and for society as a whole. However, they face multiple stressors such as academic overload, constant pressure to succeed, competition with peers and in some countries financial burden and concerns about the future. As all this may lead to psychopathology, the health of university students has been the subject of increasing focus in recent years.Multiple protective and risk factors are involved in the psychological well being and distress of university students. Specific risk factors for the development of psychopathology are high test anxiety, lower self-efficacy, as well as certain personality traits. Moreover, some students arrive at college with already existing mental health problems. The most frequent mental disorders among students are substance abuse, depression, self-harm and suicide, eating and anxiety disorders.Acquiring and improving knowledge about the student population is a crucial factor in the development of mental health promotion programs in order to meet their needs and to help them cope with various problems. Better understanding and care of the personality profile of university students can be helpful in academic and career choice and prevention of future mental health problems.