DOI: 10.1097/EDE.0b013e318176bf98
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PMID: 18552589
Issn Print: 1044-3983
Publication Date: 2008/07/01
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Abstract
Background:An increased risk of non-Hodgkin lymphoma (NHL) has been reported among long-term users of tricyclic antidepressants.
Methods:The incidence of NHL among 43,932 users of any antidepressant medication (2 or more prescriptions) in the county of North Jutland, Denmark, during 1989–2003 was compared with NHL incidence in all those not using antidepressants (0 or 1 prescription). We used Poisson regression analysis adjusted for age, sex, period, use of immunosuppressive drugs, corticosteroids, or nonsteroidal anti-inflammatory drugs.
Results:Use of tricyclic antidepressants was associated with an overall increased incidence of NHL (adjusted incidence rate ratio [IRR] = 1.53; 95% confidence interval [CI] = 1.06–2.21) compared with nonuse. The IRR in users with ≥10 prescriptions and 5 or more years of follow-up was 2.50 (CI = 1.43–4.34). Users of other types of antidepressants were not at increased risk of NHL.
Conclusions:Our results indicate an increased risk of non-Hodgkin lymphoma specifically among long-term users of tricyclic antidepressant medications.
