AMPA, KA and NMDA receptors are expressed in the rat DRG neurones


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Abstract

THE localization of AMPA receptor subunits (GluR1–4), a KA receptor subunit (GluRS) and NMDA receptor sub-units (NR1 and NRgbs; the glutamate binding subunits of an NMDA receptor complex) was investigated using immunohistochemistry and in situ hybridization histo-chemistry in the rat dorsal root ganglion. Small neurones expressed GluR1-, GluR2/3-like immunoreactivities and GluRS, NR1, NRgbs mRNAs, while large neurones expressed GluR2/3-like immunoreactivity and NR1 and NRgbs mRNAs. These data suggest that the glutamater-gic system plays an important role in the primary sensory afferent systems and that the composition of glutamate receptors differs according to the cell size.

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