PMID: 9694221

Issn Print: 0959-4965

Publication Date: 1998/07/13


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Direct inhibitory effect of taurine on relay neurones of the rat olfactory bulb in vitro

Michelino Puopolo; Igor Kratskin; Ottorino Belluzzi

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Author Information: Dipartimento di Scienze Biomediche e Terapie Avanzate, Sezione di Fisiologia Umana, Università di Ferrara, Via Fossato di Mortara 17/19, 44100 Ferrara, Italy; Smell and Taste Center, University of Pennsylvania School of Medicine, 5 Ravdin, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA

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Abstract

WHOLE-CELL recordings in rat olfactory bulb slices showed that bath application of 5 mM taurine produces a potent and reversible inhibition of identified mitral and tufted cells. Under current-clamp conditions, a shift of the membrane potential toward the chloride equilibrium potential and a 75% reduction in the membrane resistance were observed. These effects were strongly blocked by bicuculline (10 μM), but not by GABAB antagonist and strychnine, and completely maintained under the blockage of synaptic transmission. The results suggest that inhibition of bulbar relay neurons produced by taurine is primarily due to direct activation of somatic GABAA receptors and initiation of chloride conductance. This study demonstrates for the first time the actions of taurine in the olfactory system.

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