Issn Print: 0959-4965

Publication Date: 1999/07/13


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AMPA-type glutamate receptor subunits are expressed in the avian cochlear hair cells and ganglion cells

Diana Reng; Iris Hack; Marcus Müller; Jean W. Th Smolders

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Author Information: Klinikum der J. W. Goethe Universität, Physiologisches Institut III, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany

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Abstract

THE cellular localization of AMPA-type glutamate receptor subunits was examined in the pigeon inner ear using subunit specific polyclonal antibodies (GluR1–4). In the auditory ganglion cell bodies immunoreactivity for the subunits GluR2/3 and GluR4, but not for GluR1 was detected. The hair cells showed diffuse immunoreactivity for GluR4. Additionally, immunostaining for the subunits GluR2/3 and GluR4 was present below the hair cells. These results indicate that the AMPA type glutamate receptors play a role in neurotransmission at the hair cell afferent synapse in the avian auditory system.

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