Endogenous GLP-1 modulates hippocampal activity in β-amyloid protein-treated rats

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WE examined the relationship between the histochemical distribution of endogenous GLP-1 (7-36) amide in the hippocampus and memory impairment assessed by a step-through type passive avoidance task in rats continuously infused with β-amyloid protein (1-40) into the lateral cerebroventricle using a mini-osmotic pump. Our results demonstrated that endogenous GLP-1 (7-36) amide appears in the hippocampus accompanied by progression of memory impairment. Electrophysiological studies also indicated that endogenous GLP-1 inhibits hippocampal neuronal activity in β-amyloid protein-treated rats.

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