Language-impaired children: No sign of the FOXP2 mutation

E. Meaburn;P. S. Dale;I. W. Craig;R. Plomin;

Neuroreport. 13(8):1075-1077, JUN 2002

PMID: 12060812

Issn Print: 0959-4965

Publication Date: 2002/06/01

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E. Meaburn;P. S. Dale;I. W. Craig;R. Plomin;

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Abstract

A mutation in the FOXP2 gene has been found to be responsible for the autosomal dominant inheritance of a severe form of speech and language impairment in a family known as KE. We genotyped the FOXP2 mutation for 270 4-year-old children selected for low general language scores from a representative community sample of more than 18,000 children. No language-impaired child had the FOXP2 mutation. Although rare severe disorders such as those of the KE family are often caused by a single gene, common disorders such as language impairment are more likely to be the quantitative extreme of the same multiple genetic factors responsible for heritability throughout the distribution.


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Language-impaired children: No sign of the FOXP2 mutation

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