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To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case–control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy controls. The frequency of A allele in Parkinson disease was significantly higher than in the control (P=1.24×10−4, odds ratio 2.63, 95% confidence interval 1.56–4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population.