DOI: 10.1097/01.aids.0000218563.12897.ba

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PMID: 16549983

Issn Print: 0269-9370

Publication Date: 2006/04/04


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Interferon-γ decreases replication of primary R5 HIV-1 isolates in thymocytes

Livia Pedroza-Martins; W John Boscardin; Deborah J Anisman-Posner; Beverly N Redsar; Yvonne J Bryson; Otto O Yang; Christel H Uittenbogaart

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Author Information: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA

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Abstract

As interferon-γ (IFN-γ) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-γ influences HIV-1 replication in thymocytes. IFN-γ significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3hiCD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-γ may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output.

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