DOI: 10.1097/01.aids.0000247124.35129.e1

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PMID: 16988524

Issn Print: 0269-9370

Publication Date: 2006/10/03


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APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians

Han Sang Valcke; Nicole F Bernard; Julie Bruneau; Michel Alary; Christos M Tsoukas; Michel Roger

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Author Information: Laboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier

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Abstract

The cytosine deaminase APOBEC3G has been identified as a host factor that inhibits HIV-1 replication. We investigated whether genetic variants of APOBEC3G that could potentially affect the protein's expression or function were associated with the risk of infection in 122 Caucasians highly exposed to HIV-1. A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that there might be a role for APOBEC3G in susceptibility to HIV-1 infection that warrants further investigation.

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