DOI: 10.1097/QAD.0b013e3283543da4
,
,
PMID: 22592072
Issn Print: 0269-9370
Publication Date: 2012/06/01
Toll-like receptor-2 ligand lipomannan from Mycobacterium tuberculosis does not stimulate inflammatory cytokines in dendritic cells
Pushpa Hegde; Srini V. Kaveri; Jagadeesh Bayry
+ Author Information
Author Information: Institut National de la Santé et de la Recherche Médicale Unité 872, 15 rue de l’Ecole de Médicine, Paris
Excerpt
HIV patients display high incidence of dual infections with Mycobacterium tuberculosis. Some of these patients develop mycobacterial immune restoration disease (IRD) [1]. As Toll-like receptors (TLR) play a critical role in the host immune response to M. tuberculosis[2], Tan et al.[3], recently examined the role of TLR-2-induced cytokine responses in IRD patients. By using a TLR-2 ligand lipomannan from a nonpathogenic Mycobacterium smegmatis, the authors show that lipomannan induces high levels of tumor necrosis factor (TNF)α and interleukin (IL)-12p40 in mycobacterial IRD patients. Based on these results, they conclude that TLR-2-mediated activation of dendritic cells and monocytes/macrophages may contribute to proinflammatory responses and pathogenesis of mycobacterial IRD.
Facebook
Twitter
LinkedIn
Email
